Beta glucan is a carbohydrate polymer generally derived from the cell wall of baker’s yeast, oats, barley and mushrooms. Beta glucan isolated from the oats and barley are D-glucose bonded by 1,3; 1,4 beta glycosidic linkages while beta glucans extracted from the yeast and mushroom are bonded by 1,3; 1,6 beta glycosidic linkages. Numerous scientific studies have shown beta glucans in the 1,3; 1,6 beta-glycosidic linkages effectively mobilize the immune system by bonding to the receptors of the white blood cells (WBC) including the macrophages, T cells, and the Natural Killer (NK) cells. (Lindequist et al., The Phamacological Potential of Mushrooms, 2005). The Macrophages (monocytes), Granulocytes (Neutrophil, Eosinophils, and the Basophils), and the Natural Killer (NK) cells serve as our body’s frontline defense, responsible for finding, identifying, and consuming foreign invaders in our body. Furthermore, the activation of these frontline defensive also activates other components of the immune system to produce B-cells, T-cells and natural killer (NK) cells.
Mushroom Beta Glucan (MBG) is the beta 1,3;1,6 D-glucan extracted from the medicinal mushrooms. Structure wise, mushroom beta glucan is a carbohydrate polymer with chain of glucose molecules bonded by beta-glycosidic linkages. It is one of the main components of the cell wall in most mushrooms. These polymers have a diverse structural variability including molecular weight, linkage patterns, and degree of branching, triple helical conformation and water solubility. In terms of application, mushroom derived beta glucan have been claimed to be more versatile due to the water solubility nature that can be isolated without any organic/inorganic solvent such as ethanol.
No, traditional industrial extraction processes utilizing hot water and/or ethanol will potentially denature the molecular structure, thus diminishing the effectiveness. Eventually, to preserve the natural quality and benefits of the mushroom beta glucan, our engineers adopted a proprietary solvent-free process using ultrasounds to isolate the natural biopolymers within the mushrooms.
Mycelial biomasses are alternative, label dressing terms for grind-down mushroom powder which contains approximately 40% fiber and 60% protein content when moisture is taken off the equation. On the other hand, mushroom beta glucan is the unique carbohydrate component within the mushrooms that are bioavailable by binding the the receptors of the innate immune cells. The composition of the mushroom beta glucan within a mushroom is approximately <0.1%.
Our scientists believe that mushroom extracted beta glucan, along with our signature formulation to preserve long term effectiveness, demonstrate superior immune modulating result comparable to its Baker’s Yeast cousin. The difference between the complex between the mushroom beta glucan and the Baker’s Yeast derived ones is that, despite the similarity between the Beta 1,3 1,6-D Glucan derived from both, mushroom beta glucan contains Lectin, which can be defined as a protein decipher of glycocode, specifically binds or cross-links carbohydrates. There are tens of thousands of unique lectins currently identified and cataloged by the science community. One such lectin is from the Agaricus blazei Murril mushroom and has been found to avidly bind with the Thomsen-Friedenreich antigen (Gal beta-1,3-GalNAc) specific receptors exclusively expressed on tumor cells and found on the membrane of 80 to 90 percent of all known cancer cells. This lectin has been reproduced by various pharmaceutical manufactures via chemical synthesis. This may be due to protein folding or the configuration requirements for binding, but SBG believes no company has been successful in artificially reproducing the molecule for general use.
Another difference is the ability to dissolve in water. As the mushroom beta glucan harness a shorter beta-1,3 glycosidic chain, it is naturally water soluble as compared to the yeast derived one, which is naturally water insoluble.
Yes, not only are all our ingredients organically cultured, they’re also extracted with an environmental friendly procedure with absolutely no animal by-products to keep up to the environment-friendly trend.
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